Type rr <start> to <destination> in Alfred to find route options. Get Autocomplete suggestions as you type.

The search results are displayed one route at a time.

Hit Tab key to cycle through all available routes. The first item is the route description, and you can select that option to view full details on the rome2rio web site, or press the Shift key for a preview.

The items that follow make up the various stops and segments of the trip - press Shift to get a map displayed highlighting the start and end points of each segment.

To reset your search, hit Cmd + Enter on a route description. Or just type rr <start> to <destination> again to begin a new search